Bidirectional association between periodontitis and type 2 diabetes

The recognition of the relationship of periodontal disease to general health, including type 2 diabetes, has revealed new perspectives regarding prevention and treatment.


It may sound strange, but beyond obesity there are other factors that are less well known for risk of type 2 diabetes.

Today I am going to refer to periodontitis as a risk factor for diabetes. And vice versa; because diabetes is also a risk factor for periodontitis.

How can periodontitis and type 2 diabetes be related?

In the article published in Nature “Diabetes mellitus and periodontitis: a tale of two common interrelated diseases”:

  • NATURE periodontitis & type 2 diabetes Diabetes leads to a hyper-inflammatory response. In these circumstances, the possible repair of the effects of bacterial plaque in the oral cavity is impaired due to the capacity of the receptors and cellular ligands involved in our defenses. Diabetes implies a risk for periodontitis.
  • At the same time, periodontitis negatively affects glycemic control in those patients with diabetes and thus contributes to the development of their complications. The adverse effect of periodontal infections on diabetes is explained in principle by increased systemic inflammation, which in some way contributes to insulin resistance. And in this case, it can be concluded that periodontitis is a risk for diabetes.

And then, what can we do?

Patients with uncontrolled diabetes are prone to periodontitis and periodontitis is associated with poorer blood glucose control, which is associated with microvascular complications.

In addition, periodontitis may also contribute to macrovascular complications through systemic inflammation and consequently to problems associated with poorer control of plasma lipids (cholesterol, triglycerides, etc.). Dentista y diabetes tipo 2Therefore, periodontitis is a strong predictor of mortality from cardiac or renal complications in patients with diabetes.

According to a recent intervention study, regular check-ups with the dentist could be a key element in the effective treatment of type 2 diabetes. In this study it was found that the reduction in glycated hemoglobin among patients with diabetes who received treatment for their periodontitis was like that expected with pharmacological treatment.

Thus, in both, predisposed patients and those who are already diagnosed, a check-up at the dentist is recommended, at least every two years, to carry out an in-depth oral hygiene and remove, if necessary, the bacterial plaque, also called dental or oral biofilm.



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Juan Revenga Frauca
I am Dietician-Nutritionist and Biologist from the University of Navarra and I practice the profession of dietician-nutritionist and as professor at San Jorge University. I am also a collaborator in different media in the fields of nutrition, food and health . I am member of the Spanish Foundation for Dietitians and Nutritionists (FEDN), and part of both its Scientific Committee and its Technical Advisory Committee. I have been president and founder of the Professional College of Aragon D-N (CPDNA). I am an active user of social media. You can follow me on twitter (@juan_revenga) or Facebook.